Medicinal Chemistry and Drug Design

Understand drug-receptor interactions, SAR analysis, and the process of designing new pharmaceutical compounds.

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Course Outline

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1. Molecular Docking Techniques: Explore computational methods to predict how small molecules, such as drug candidates, bind to a receptor of known 3D structure.

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2. Pharmacophore Modeling: Learn to identify the essential features of molecules that are necessary for biological activity.

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3. ADMET Properties: Understand Absorption, Distribution, Metabolism, Excretion, and Toxicity, which are crucial in drug formulation.

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4. Structure-Based Drug Design: Delve into techniques that rely on molecular structures to develop new drugs.

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5. Fragment-Based Lead Discovery: Study methodologies that utilize small chemical fragments to improve drug development efficiency.

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6. High-Throughput Screening (HTS): Examine techniques for rapidly assessing thousands of potential drug compounds.

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7. Drug Metabolism Pathways: Investigate the biochemical processes that alter drug compounds post-administration.

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8. Biologics and Biosimilars: Understand the development, manufacturing, and regulatory aspects of biologically-derived drugs.

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9. Medicinal Chemistry of Natural Products: Analyze the contributions of natural substances in drug development.

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10. Clinical Trials Phases: Gain insight into the various stages of clinical testing for new pharmaceutical products.

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